Jack3d

Jack3d Advanced taste

You’re no stranger to the weight room and you’ve surely tried your fair share of pre-workout products. You might not even care what the product tastes like, as long as it works.

Most of the time it’s even a disappointing trade off—great taste with nothing but poor performance and a sub-par caffeine rush followed by a depressing crash.

That might be fine for the noobs, but not for you; you’re searching for the real deal pre-workout that gives you the best of everything…Good luck!
What if there was a product that Worked Phenomenally AND Tasted Amazing too? Enter Jack3d® “Advanced Formula”.

USPlabs contracted industry-leading flavor scientists and gave them one very specific goal: make this the best tasting pre-workout ever and, wow, did they ever deliver.

Don’t forget that there aren’t any carbs in Jack3d “Advanced Formula”; making the “industry-best” taste a truly mindboggling accomplishment.

Jack3d Advanced feel
The Intense Rush, the Telling Tingle, the Unapologetic Strength.

It’s like you have no choice but to Dominate the Weight Room!

However, you must be warned; this Jack3d is no joke. In fact, it’s so strong we had to slap this warning label on top of the bottle:

Jack3d High Energy Stim Complex… complete with Hard-Hitting Extracts…
This new, precise complex targets a myriad of MOAs for an incredible feel that is so unique and strong that you’ll literally need some time to acclimate. You must be absolutely sure to start with 1 scoop and NEVER go over 2 at any one time.

Norcoclaurine – is known to be a beta 2-adrenoceptor agonist (3). Some compounds also known to activate the beta 2-adrenoceptor have been shown to improve exercise performance (4) and USPlabs believes that norcoclaurine could potentially do so as well.

Yet, unlike most other beta 2 agonists, norcoclaurine has been shown to have vasodilatory properties as well! (5).

Thus, you may have improved blood flow for additional pumps and vascularity—that’s a pretty sweet “bonus”!

Swertia Chirayita – is a plant that is indigenous to the temperate Himalayas and has, for the most part, been their little secret…until now!

It has specific compounds present which animal studies have shown to possess CNS stimulant properties (6).

Caffeine – is, of course, a “must-include” in any high energy formula.

The key difference here is the precise amount included.

USPlabs’ goal was not to just include an insane amount of caffeine so you could “feel it”, but to incorporate an amount that works perfectly with other key ingredients.

When combined with norcoclaurine, caffeine could provide a substantial boost to your workout session. Yet, even on its own, caffeine is thought to potentially increase force production by each motor unit in muscle, enhancing contractile force of muscle, while reducing perceived exertion (7,8).

Jack3d Advanced performance
Exclusive “Nitrate Blast” formula!

Arginine Nitrate – allows you to utilize two major pathways to generate Nitric Oxide (NO).

When you ingest this compound, you get the classic arginine, which works through the conventional l-arginine-NO-synthase pathway and that has proven to be a decent method to elevate NO. But, Arginine Nitrate also yields the nitrate ion, which works through a recently discovered pathway, called the nitrate-nitrite-nitric oxide pathway. In essence, nitrate is reduced to nitrite, which is further reduced to NO.

Yet, this second pathway is also exciting because it can generate NO via several routes that are enzymatic and non-enzymatic, making this pathway, in some respects, a more reliable and better overall way to increase NO (9-12).

Furthermore, this pathway becomes much more important and is favored over the classical pathway in conditions where oxygen levels are much lower and to some extent acidification occurs in a given tissue (e.g. anaerobic exercise like weight lifting, sprinting, etc.), allowing for vasodilation to occur and oxygen to be transported in these conditions.

By combining the two, we can utilize both pathways to obtain extremely high NO levels to achieve a level of vasodilation never experienced before!

Also, by utilizing both pathways, you’re ensuring that NO levels can remain elevatedregardless of the phase of your activity. This increased NO and vasodilation may be partially responsible for a potential improvement of exercise efficiency by reducing the amount of oxygen and energy needed in the form of ATP and phosphocreatine during exercise and muscle contraction.

In short, it may allow you to be more resistant to fatigue and squeeze out a little more during your workouts, whether that’s just a few more reps when weightlifting or allowing you to stay in the game a little longer.

This isn’t just hype! In fact, a recently published study found that nitrate can increase force production in fast-twitch skeletal muscle in mice used as an animal model. This is further corroborated by the fact that one paper in humans found that nitrate supplementation allowed for a prolonged maintenance of force production (14,21).

It’s also worth noting that this notion of nitrate increasing vasodilation and improving exercise performance isn’t just hypothetical. Several studies have surfaced recently which have demonstrated that nitrate can and does accomplish just that (13-20).

A recent meeting summary by leading researchers of nitrate’s and NO’s shows potential by commenting that the apparent enhancement of skeletal muscle efficiency seen as a reduced oxygen cost of exercise is seen from low to high-intensity exercise and in recreationally active and moderately trained subjects (22).

Pinus Pinaster Bark Extract – This extract may further increase the conversion of nitrite to NO, while also increasing eNOS expression and NO formation, thus helping both NO generating pathways.

Vitamin C (Ascorbic acid) – Vitamin C is known to play a role in maintaining NO bioactivity/bioavailability and is the reason why it is known to improve the effects of NO, whether the NO is derived from arginine or the reduction of nitrite (23-25).

Studies suggest that vitamin C can work synergistically with the other key ingredients by improving upon both major NO-generating pathways; of particular interest is that it (as a reducing agent) can also increase the amount of NO produced from nitrite while also enhancing the level of vasodilation; yet, it also plays a role in the function of eNOS by acting to recycle tetrahydrobiopterin, a cofactor for eNOS (26, 27).

You’re not still getting ripped off by Creatine HCl, are you?
Advanced Creatine Ratio – including Creatine Monohydrate and Creatine Anhydrous. Everyone knows that creatine is able to improve body composition and strength. It’s easily one of the most validated supplements around. It works and always has worked. Yet, many companies want to sell you a creatine complex, a supposedly superior salt, a new ester, you name it, claiming it will provide superior results over tried and true creatine.

Some even make such claims with no scientific evidence (even though they will pretend it exists). They claim that bioavailability is a problem with creatine monohydrate due to lack of dissolution in the GI tract. Yet, scientific studies show otherwise.

In fact, the absorption of the creatine monohydrate salt is nearly 100% (28-30).

This begs the simplest question; if the oral bioavailability of creatine monohydrate is already close to 100%, how can it be significantly improved upon? The simple answer is that it can’t be improved upon. It’s like someone claiming they can fill the 13 gallon tank in your car with more than 13 gallons of gas. It doesn’t matter how much more soluble you make your creatine product if creatine monohydrate already has nearly 100% bioavailability.

If dissolution rate isn’t a rate-limiting step for the compound, then improving solubility does nothing for bioavailability. You simply have a neat party trick to show friends how much creatine you can dissolve in a glass of water.

Yet, just as important to consider is the fact that skeletal muscle can only absorb and store a limited amount of creatine (28-31). Even if we were to ignore the fact that oral bioavailability of creatine monohydrate has little to no room for improvement, we must then consider the fact that the muscle can only transport so much creatine and tissue saturation is going to occur regardless at some point. So, regardless of which form is used, only so much creatine is going to enter into the muscle and saturation is going to be reached at some point. For example, it’s thought that a 154 lbs. person has a total creatine content in skeletal muscle of approximately 115 g, with a total creatine pool of approximately 120 g (30,31).

And, for a specific example, a subject that was given 340 g of creatine monohydrate over a 34 day period only retained 38 g in the body. Or, in another subject that was given 270 g, only 58 g were retained (31). Studying the kinetics of creatine has provided support for this as well (28-30). In effect, this demonstrates again that skeletal muscle can only hold so much creatine and it isn’t all that much higher than the baseline levels.

Once again, bro science jumps up to get beat down
Even if we were to ignore the fact that the absorption of creatine from the small intestine is thought to be close to 100% and believe the marketing from those selling these supposedly superior forms of creatine, the higher levels of creatine in the bloodstream would make little difference as skeletal muscle can only absorb and store a limited amount of creatine. Consequently, higher plasma levels of creatine don’t mean that it will translate to higher levels of creatine in muscle. Ultimately, the level of creatine in muscle would need to be substantially higher in order for these other creatine products to be classified as being superior to creatine monohydrate and, most important of all; this higher level of creatine would need to lead to a significant improvement upon lean body mass, strength and power.

Yet, conveniently, a study comparing the effects of these creatine formulations versus standard creatine monohydrate upon these parameters has not been sought out or published. Makes you think, doesn’t it?

What if you could make your creatine more pure?
If improving solubility doesn’t matter, what about your creatine being more pure?

Some manufacturers like to claim that their creatine form is concentrated because of the salt they use, but that’s just not true.

Creatine monohydrate is already nearly 88% pure creatine (88% creatine, 12% monohydrate salt) -that’s nearly 10% more pure than products like Creatine HCl!

But, what if there was a form of creatine that was 100% creatine? Would you want that in your pre-workout?

Of course you would and that’s exactly why we included it in Jack3d “Advanced Formula”!

It has the same, if not slightly better solubility than creatine monohydrate, but provides about 12% more creatine. You can’t get any more pure than creatine anhydrous!

Beta-Alanine – serves as the rate-limiting precursor of carnosine and as such, it has been shown that by supplementing with beta-alanine, you can greatly increase carnosine levels in skeletal muscle tissue.

It’s important because it acts as a buffer of sorts, preventing the increase of acidity or Hydrogen ion accumulation in skeletal muscle; something which is thought to contribute to the fatiguing of muscles. Furthermore, there is evidence that by increasing carnosine levels, power output can be increased as well. In short, you are able to improve your power output while delaying fatigue – you can lift more explosively and for longer periods (32-35).

It is no coincidence that the most explosive athletes, such as sprinters, have higher carnosine levels in their muscles. Also, examining the animals of our world provides us with yet another example; the most explosive animals, such as greyhounds and thoroughbred horses, have the highest level of carnosine in their muscle tissue.

In short, beta-alanine supplementation has been shown to be an effective way of elevating carnosine levels in muscle. Consequently, it has been shown to increase the working capacity of muscle, elevate the buffering capacity of muscle, elevate the anaerobic threshold of muscle, promote endurance, delay fatigue during workouts, enhance exercise training and result in an overall improvement of muscle performance.

If you think beta-alanine isn’t necessary, you should also consider the fact that it is believed that muscle carnosine levels generally decline with age and are thought to be lower in those that don’t consume much meat in their diets (34).

Best,

1. Galitzky J, Taouis M, Berlan M, et al. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest. 1988 Dec;18(6):587-594
2. Inagaki T, Sonobe T, Poole DC, et al. Progressive arteriolar vasoconstriction and fatigue during tetanic contractions of rat skeletal muscle are inhibited by α-receptor blockade. J Physiol Sci. 2011 May;61(3):181-189
3. Tsukiyama M, et al. Beta2-adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestica Thunberg. Planta Med. 2009 Oct;75(13):1393-1399
4. Sanchez AM, Collomp K, Carra J, et al. Effect of acute and short-term oral salbutamol treatments on maximal power output in non-asthmatic athletes. Eur J Appl Physiol. 2012 Sep;112(9):3251-3258
5. Chang KC, Chong WS, Lee IJ. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994 Apr;72(4):327-334
6. Srivastava S, Mishra N & Misra U. Neurological studies of novel compounds from Swertia Chirayita. J. Chem. Pharm. Res. 2010 2(1):125-134
7. Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807
8. Tarnopolsky MA. Effect of caffeine on the neuromuscular system—potential as an ergogenic aid. Appl Physiol Nutr Metab. 2008 Dec;33(6):1284-1289
9. Weitzberg E, Hezel M, Lundberg JO. Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care. Anesthesiology. 2010 Dec;113(6):1460-1475
10. Lundberg JO & Weitzberg E. NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics. Arch Pharm Res. 2009 Aug;32(8):1119-1126
11. Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008 Feb;7(2):156-167
12. NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol. 2005 May;25(5):915-922
13. Larsen FJ, et al. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf). 2007 Sep;191(1):59-66
14. Bailey SJ, et al. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol. 2010 Jul;109(1):135-148
15. Larsen FJ, et al. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med. 2010 Jan 15;48(2):342-347
16. Bailey SJ, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Apply Physiol. 2009 Oct;107(4):1144-1155
17. Webb AJ, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008 Mar;51(3):784-790
18. Vanhatalo A, et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010 Oct;299(4):R1121-R1131
19. Lansley KE, et al. Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Apply Physiol. 2010. Published Ahead of Print.
20. Dejam A, et al. Effects of dietary nitrate on blood pressure. N Engl J Med. 2007 Apr 12;356(15):1590
21. Hernandez A, Schiffer TA, Ivarsson N, et al. Dietary nitrate increases tetanic [Ca2+]I and contractile force in mouse fast-twitch muscle. J Physiol. 2012 July 9. E-published ahead of print.
22. Jones AM, Vanhatalo A, Bailey SJ. Influence of dietary nitrate supplementation on exercise tolerance and performance. Nestle Nutr Inst Workshop Ser. 2013;75:27-40
23. Heller R, et al. L-ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem. 1999 Mar 19;274(12):8254-8260
24. Muller-Delp JM. Ascorbic acid and tetrahydrobiopterin: looking beyond nitric oxide bioavailability. Cardiovasc Res. 2009 Nov 1;84(2):178-179
25. Tomasian D, Keaney JF, Vita JA. Antioxidants and the bioactivity of endothelium-derived nitric oxide. Cardiovasc Res. 2000 Aug 18;47(3):426-435
26. Carlsson S, et al. Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. Nitric Oxide. 2001 Dec;5(6):580-586
27. Modin A, et al. Nitrite-derived nitric oxide: a possible mediator of ‘acidic-metabolic’ vasodilation. Acta Physiol Scand. 2001 Jan;171(1):9-16
28. Deldicque L, Decombaz J, Zbinden Foncea H, et al. Kinetics of creatine ingested as a food ingredient. Eur J Appl Physiol. 2008 Jan;102(2):133-143
29. Jager R, Harris RC, Purpura M, et al. Comparison of new forms of creatine in raising plasma creatine levels. J Int Soc Sports Nutr. 2007 Nov 12;4:17
30. Persky AM, Muller M, Derendorf H, et al. Single-and multiple-dose pharmacokinetics of oral creatine. J Clin Pharmacol. 2003 Jan;43(1):29-37
31. Chanutin A. The fate of creatine when administered to man. J Biol Chem. 1926 67(1):29-41
32. Derave W, et al. Muscle canosine metabolism and beta-alanine supplementation in relation to exercise and training. Sports Med. 2010 Mar 1;40(3):247-263
33. Sale C, et al. Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance. Amino Acids. 2010 Jul;39(2):321-333
34. Artioli GG, et al. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. 2010 Jun;42(6):1162-1173
35. Harris RC, Sale C. Beta-alanine supplementation in high-intensity exercise. Med Sport Sci. 2012;59:1-17